Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish, Published online: 06 July 2018; doi:10.1038/s41467-018-05105-8

The functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins.

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