Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells

Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells

Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells, Published online: 05 July 2018; doi:10.1038/s41467-018-05038-2

Feeder cells are widely used for the culture of embryonic stem cells (ESCs), but their specific effects are not well known. Here, the authors demonstrate that mouse ESCs exhibit telomere loss and chromosomal aberrations associated with reduced Zscan4 with increasing passages in the absence of feeders

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