Glycan recognition in globally dominant human rotaviruses
Glycan recognition in globally dominant human rotaviruses, Published online: 06 July 2018; doi:10.1038/s41467-018-05098-4
Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and age-restricted tropism of RVs.
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