LARGE, an intellectual disability-associated protein, regulates AMPA-type glutamate receptor trafficking and memory [Neuroscience]

Mutations in the human LARGE gene result in severe intellectual disability and muscular dystrophy. How LARGE mutation leads to intellectual disability, however, is unclear. In our proteomic study, LARGE was found to be a component of the AMPA-type glutamate receptor (AMPA-R) protein complex, a main player for learning and memory…

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