microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site, Published online: 04 July 2018; doi:10.1038/s41467-018-05053-3

The liver-specific microRNA-122 is an essential proviral host factor of Hepatitis C virus replication. Here the authors show that microRNA-122 functions as an RNA chaperone that guides the formation of a functional internal ribosome entry site by preventing energetically more favorable secondary structures within the HCV RNA genome.

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