Sodium and proton coupling in the conformational cycle of a MATE antiporter from Vibrio cholerae [Biophysics and Computational Biology]

Secondary active transporters belonging to the multidrug and toxic compound extrusion (MATE) family harness the potential energy of electrochemical ion gradients to export a broad spectrum of cytotoxic compounds, thus contributing to multidrug resistance. The current mechanistic understanding of ion-coupled substrate transport has been informed by a limited set of…

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